December 15, 2025
The young hematologist, Dr. Concetta, greeted us with a smile at the Cancer Institute. It had been six months since Sandy’s last appointment, but the doctor didn’t waste time on small talk. She waved an eight-page report, then sat and leaned forward to explain it.
“Hemoglobin, platelets, creatine look good. Kappa light chain reading is down. Kidneys look great. You’re doing great,” she said.
She talked about other things in the report, columns of terms and figures you would need a medical degree to decipher. We understood this was good news. We relaxed and chatted about the Vietnam trip next month, about the scramble to get the right vaccinations. “Sounds wonderful,” the doc said. We exchanged Merry Christmases and got out of there. Another medical escape.
All this started more than a year ago when a urologist sent her for blood testing. Kidneys are complicated things. They don’t like excessive protein, which may be produced in the body by processes that require a specialty in urology to understand. It can lead to an obscure condition—obscure to us—called “monoclonal gammopathy of undetermined significance,” or MGUS, the “undetermined” being key.
MGUS Kappa light chain is a risk condition for multiple myeloma, or blood cancer, which has no cure. It’s a low risk for most folks, we learn, but who’s the “most” and who’s not? Like lots of potential conditions for old folks, no one really knows. What you do know is that the possibility will keep you awake at night.
We were lucky. All this started with a friendly nurse practitioner who ordered some tests and referred us to a urologist. Referrals grind along slowly for urologists, after all, most old folks need to see them. In my kidney cancer days of 2019, the waiting room always was packed with seniors, friendly and chatting or silent, eyes closed. No one minded waiting, all felt lucky to have an appointment.
Sandy’s specialist wanted more tests. Blood test results, after all, are a critical indicator of lots of things. She is not one for being jabbed. Months later we got to the Cancer Institute and hematology with Dr. Concetta. She looked at the tests, ordered more, and set an appointment in three months. Meanwhile we googled Kappa light chain and MGUS.
We did what we could in the way of healthy living. Sandy gave up drinking diet soda, a lifelong habit. We ate more fresh vegetables and salads and cut back on meat. We quit the pork loin we used to grill using what seemed like a healthy recipe in The Fat Chance Cookbook. We ate grilled salmon and veggie burgers. We switched from sugary yogurt to plain.
She kept up her water aerobics classes at the YMCA and went to the gym.
All this is the conventional wisdom, the things you’re supposed to do, young or old. The hard part is finding whether it has any effect on the mysterious chemical composition of your blood and the progression of MGUS-Kappa light chain.
The doc gave us a copy of the report. The first page looked good, I guessed, the figures in the column of new results was lower for types of protein, by a fraction, than six months ago. The following pages were a barrage of abbreviations and acronyms. I recognized “Basic Metabolic Panel” from my own parade of blood tests: sodium, potassium, chloride, CO2, BUN, calcium, creatine, glucose. Most old folks, and some younger ones, would recognize them.
The report offered more cryptic numbers, but we took our cues from the doctor’s cheerful mood. Whatever the report says, you’re okay if she’s smiling. The doctor’s expression tells you what shape you’re really in.
Cancer and its precursor conditions are everywhere. After the appointment we talked to our son Michael, a medical physicist and director of resident physicists at Cooper Hospital in New Jersey, part of the M.D. Anderson Medical Group. He explained the use of statistical calculations to analyze the treatment of 1,000 cancer patients. One thousand patients? One hospital?

Our local Cancer Institute is a compact two-story building. Usually a dozen folks are waiting for appointments. Getting a seat is never a problem. But that’s a dozen when I’m there for an hour. Others are waiting when I leave, and that’s five days a week. There’s another cancer institute nearby in the suburbs, and satellite offices all over the county. So a thousand patients? Easily.
M.D. Anderson, the nation’s premier cancer center, partners with seven hospitals nationwide and one in Spain. Other major cancer hospitals reach through the country. The Mayo Clinic is in Minnesota, Arizona, and Florida. Sloan-Kettering is in New York City, Long Island, and New Jersey. Prisma Health has dozens of hospitals in South Carolina and Tennessee.
Those places, and many others, treat thousands and thousands of patients, who go through test after test using technologies that generate vast piles of data, to be parsed by sophisticated statistical methodologies. Medicine and computer science are integrated, blended, mulched, to spit out figures incomprehensible to the average patient (most of us). We don’t follow the briefing or stare at the paperwork. Instead we look for a smile.





